Publications, Page 2

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Abeta oligomers.

De Felice, FG, Wu, D, Fernandez, SJ, Velasco, PT, Lacor, PN, Bigio, E, Jerecic, J, Acton, PJ, Shughrue, PJ, Chen-Dodson, E, Kinney, GG and Klein, WL (2008)Neurobiology of Aging 

Amyloid beta oligomers induce impairment of neuronal insulin receptors.

Zhao, WQ, De Felice, FG, Fernandez, SJ, Lambert, MP, Krafft, G and Klein, WL (2008)FASEB Journal

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine.

De Felice, FG, Velasco, PT, Viola, KL, Fernandez, SJ, Ferreira, ST and Klein, WL (2007) Journal of Biological Chemistry 

Monoclonal antibodies that target pathological assemblies of Abeta.

Lambert, MP, Velasco, PT, Chang, L, Viola, KL, Fernandez, SJ, Lacor, PN, Khuon, D, Cong, Y, Bigio, E, Shaw, P, De Felice, FG, Krafft, G. and Klein, W. L. (2007)  Journal of Neurochememistry 

Latin American challenges.

De Felice, FG (2007) Nature 450: 316. 

Soluble oligomers from a non-disease related protein mimic Abeta-induced tau hyperphosphorylation and neurodegeneration.

Vieira, MNN, Forny-Germano, L, Saraiva, LM, Sebollela, A, Martinez, A MB, Houzel, JC, De Felice, FG and Ferreira, S.T. (2007)  Journal of Neurochemistry

Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases.

Ferreira, ST, Vieira, MNN and De Felice, FG (2007) IUBMB Life 59: 332-345. 

Formation of soluble oligomers and amyloid fibrils with physical properties of the scrapie isoform of the prion protein from the C-terminal domain of recombinant murine prion protein mPrP-(121-231)

Martins, SM, Frosoni, DJ, Martinez, AMB; De Felice, FG and Ferreira, ST (2006) Journal of Biological Chemistry

Metastable, partially folded states in the productive folding and in the misfolding and amyloid aggregation of proteins.

Ferreira, ST, De Felice, FG and Chapeaurouge, A (2006) Cell Biochemistry and Biophysics

Mitochondrial creatine kinase activity prevents reactive oxygen species generation: antioxidant role of mitochondrial kinase-dependent ADP re-cycling activity.

Meyer, LE, Machado, LB, da Silva, WS, Holub, O, Santiago, APSA, De Felice, FG; Oliveira, MF and Galina, A (2006) Journal of Biological Chemistry

Novel neuroprotective, neuritogenic and anti-amyloidogenic properties of 2,4-dinitrophenol: The gentle face of Janus.

De Felice, FG and Ferreira, ST (2006) IUBMB Life 

Small molecule inhibitiors of lysozyme amyloid aggregation.

Vieira, MNN, Figueroa-Villar, JD, Meirelles, MNSL, Ferreira, ST and De Felice, FG (2006)Cell Biochemistry and Biophysics

Stabilization of partially folded states in protein folding/misfolding transitions by hydrostatic pressure. 

Ferreira, ST, Chapeaurouge, A, De Felice, FG (2005) Brazillian Journal of Medical Biology and Research

Activation of GABA(A) receptors by taurine and muscimol blocks the neurotoxicity of beta-amyloid in rat hippocampal and cortical neurons.

Paula-Lima, AC, De Felice, FG, Brito-Moreira, J, Ferreira, ST (2005) Neuropharmacology. 

Neuritogenesis and neuronal differentiation promoted by 2,4-dinitrophenol, a novel anti-amyloidogenic compound.

Wasilewska-Sampaio, AP, Silveira, MS, Holub, O, Goecking, R, Gomes, FC, Neto, VM, Linden, R, Ferreira, ST, De Felice, FG (2005) FASEB Journal 19(12):1627-36 

Mitochondrial bound hexokinase activity as a preventive antioxidant defense: Steady-state ADP formation as a regulatory mechanism of membrane potential and reactive oxygen species generation in mitochondria.

da-Silva, WS, Gomez-Puyou, A, de Gomez-Puyou, MT, Moreno-Sanchez, R, De Felice, FG, de Meis, L, Oliveira, MF and Galina, A (2004) Journal of Biological Chemistry 

Targeting the neurotoxic species in Alzheimer's disease: Inhibitors of Abeta oligomerization.

De Felice, FG, Vieira, MN, Saraiva, LM, Figueroa-Villar, JD, Garcia-Abreu, J, Liu, R, Chang, L, Klein, WL and Ferreira, ST (2004). FASEB Journal 

Formation of amyloid fibrils from human lysozyme and its disease-associated variants using hydrostatic pressure.

De Felice, FG, Vieira, MN, Meirelles, MN, Morozova-Roche, LA, Dobson, CM and Ferreira, ST (2004) FASEB Journal

Beta-amyloid production, aggregation and clearance as targets for treatment in Alzheimer's disease.

De Felice, FG and Ferreira, ST (2002) Cell. Mol. Neurobiol.22:529-547.

De Felice, FG and Ferreira, ST (2002) Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer’s disease. Anais da Academia Brasileira de Ciencias (invited review).

Protein dynamics, folding and misfolding: from basic physical chemistry to human conformational diseases.

Ferreira, ST and De Felice, FG (2001) FEBS Letters

De Felice, FG, Houzel, JC, Garcia-Abreu, J, Louzada, PRJr., Afonso, RC, Meirelles, MN, Lent, R, Neto, VM and Ferreira, ST (2001) Inhibition of Alzheimer’s disease beta-amyloid aggregation, neurotoxicity and in vivo deposition by nitrophenols: implications for Alzheimer’s treatment. FASEB Journal