Featured Publications

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AAV-mediated neuronal expression of an scFv antibody selective for Aβ oligomers protects synapses and rescues memory in Alzheimer models.

Selles MC, Fortuna JTS, Cercato MC, Santos LE, Domett L, Bitencourt ALB, Carraro MF, Souza AS, Janickova H, Azevedo CV, Campos HC, De Souza JM, Alves-Leon S, Prado VF, Prado MAM, Epstein AL, Salvetti A, Longo BM, Arancio O, Klein WL, Sebollela A, De Felice FG, Jerusalinsky DA, Ferreira ST.  (2022) Molecular Therapy.

Cerebrospinal fluid irisin and lipoxin A4 are reduced in elderly Brazilian individuals with depression: Insight into shared mechanisms between depression and dementia.

Gonçalves RA, Sudo FK, Lourenco MV, Drummond C, Assunção N, Vanderborght B, Ferreira DDP, Ribeiro FC, Pamplona FA, Tovar-Moll F, Mattos P, Ferreira ST, De Felice FG. (2022) Alzheimer's & Dementia.

Lung inflammation induced by silica particles triggers hippocampal inflammation, synapse damage and memory impairment in mice.

Suman PR, Lisiane SS, Kincheski GC, Melo HM, Machado MN, Carvalho GMC, De Felice FG, Zin WA, Ferreira ST. (2022) Journal of Neuroinflammation.  

Irisin stimulates protective signaling pathways in rat hippocampal neurons. 

Lourenco MV, De Freitas GB, Raony I, Ferreira ST, De Felice FG. (2022) Irisin stimulates protective signaling pathways in rat hippocampal neurons. Frontiers in Cellular Neuroscience.

The emerging neuroprotective roles of exerkines in Alzheimer's disease.  

Rody T, De Amorim JA, De Felice FG. (2022) The emerging neuroprotective roles of exerkines in Alzheimer's disease. Frontiers in Aging Neuroscience.

Characterization of cerebrospinal fluid biomarkers associated with neurodegenerative diseases in healthy cynomolgus and rhesus macaque monkey.

Robertson EL, Boehnke SE, Lyra e Silva NM, Armitage-Brown B, Winterborn A, Cook DJ, De Felice FG, Munoz DP. (2022) Alzheimer's & Dementia (New York, NY).

Inflammation at the crossroads of COVID-19, cognitive deficits and depression.

Lyra e Silva N, Barros-Aragao F, De Felice FG, Ferreira ST. (2022) Neuropharmacology.  

Impaired insulin signaling and allostatic load in Alzheimer’s disease.

De Felice FG, Goncalves RA, Ferreira, ST. (2022) Nature Reviews Neuroscience.

Cerebrospinal Fluid Neurotransmitters, Cytokines, and Chemokines in Alzheimer's and Lewy Body Diseases. 

Lourenco MV, Ribeiro FC, Santos LE, Beckman D, Melo HM, Sudo FK, Drummond C, Assunção N, Vanderborght B, Tovar-Moll F, De Felice FG, Mattos P, Ferreira ST. (2021) Journal of Alzheimer's Disease

The crosstalk between brain and periphery: Implications for brain health and disease.

Gonçalves RA, De Felice FG. (2021) Neuropharmacology.

Combination of human tau and islet amyloid polypeptide exacerbates metabolic dysfunction in transgenic mice.

Wijesekara N, Goncalves RA, De Felice FG,Fraser PE. (2021). The Journal of Pathology  

Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease. 

Lyra e Silva N, Gonçalves RA, Pascoal T, Filho RL, Teixeira A, Vieira E, Penny JA, Clarke JR, Tiemi J, Furigo I, Coreixas V, Longo BM, Hashiguchi D, Donato Jr. J, Fraser PE, Neto PR, Caramelli P, Ferreira ST, De Felice FG. (2021) Translational Psychiatry

Interleukin-1β mediates alterations in mitochondrial fusion/fission proteins and memory impairment induced by amyloid-β oligomers.

Batista AF, Rody T, Forny-Germano L, Cerdeiro S, Bellio M, Ferreira ST, Munoz, DP, De Felice FG. (2021) Journal of Neuroinflammation 

Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity and memory in mouse models of Alzheimer’s disease.  

Oliveira MM, Lourenco MV, Longo F, Kasica NP, Yang W, Ureta G, Ferreira DDP, Mendonça PHJ, Bernales S, Ma T, De Felice FG, Klann E, Ferreira ST. (2021) Science Signalling

Dementia in Latin America: Paving the way towards a regional action plan. 

Parra M, Baez S, Sedeño L, Gonzalez-Campo C, Santamaría-García H, Aprahamian I, Bertolucci P, Bustin J, Bicalho MC, Cano-Gutierrez C, Caramelli P, Chaves M, Cogram P, Costa-Beber B, Court F, Cruz de Souza L, Custodio N, Damian A, de la Cruz M, Rodriguez RD, Brucki SD, Peñailillo LD, Engler H, Chaves MLF, Fajersztajn L, Farías G, De Felice FG; Mata IF, Ferrari R, Oliveira FF, Ferreira ST, Ferretti C, Balthazar MF, Fuentes P, Frota NF, García A, Garcia P, Porto FG, González-Billault C, Guerrero A, Huepe D, Pio FJ, Suemoto CK, Kochhann R, Kochen S, Kumfor F, Lanata S, Mansur LL, Lie M, Lillo P, Guerra JL, Lira D, Lopera F, Lopez O, Solis PL, Ferretti-Rebustini REL, Manes F, Martin J, Matallana D, Mbakile-Mahlanza L, Ton AMM, Tavares RM, Miotto E, Miller B, Moguilner S, Morelli L, Muniz-Terrera G, Muñoz-Nevárez L, Nitrini R, Orozco D, Piguet O, Oliveria MO, Caipa MP, Escudero SP, Schilling LP, Quiroz Y, Palmeira AR, Yassuda MS, Santacruz J, Serafim R, Smid J, Slachevsky A, Serrano C, Soto-Añari M, Takada LT, Grinberg LT, Teixeira A, Barbosa MT, Torralva T, Trépel D, Vasquez R, Weisstaub N, Ibanez A (2021) Alzheimer's & Dementia

The Latin America and Caribbean Consortium on Dementia (LAC-CD): The impact of SARS-CoV-2 in dementia across Latin America: A call for urgent regional plan and coordinated response. 

Ibanez A, Santamaria-Garcia H, Guerrero-Barragan A, Kornhuber A, Marques-Ton AM, Slachevsky A, Teixeira AL, Mar-Meza BM, Serrano CM, Cano C, Arias-Gonzalez C, Gonzalez-Billault C, Butler C, Bustin J, Duran-Aniotz Cm, Acosta D, Matallana DL, Acosta-Alvear D, Trépel D, França-Resende EDP, Ferreira de Oliveira F, Ibanez F, De Felice FG, Navarrete G, Tarnanas I, Meier IB, Smid J, Llibre-Guerra J, Llibre-Rodriguez JJ, Fajersztajn L, Tadao-Takada L, Duque L, de Oliveira MO, Camargos-Bicalho MA, Behrens MI, Pintado-Caipa M, Parra-Rodriguez MA, Wilson MZ, De La Cruz Puebla M, Custodio N, Santibanez R, Bernardo-Serafim R, Melo-Tavares R, Piña-Escudero SD, Rodriguez TL, Dawson W, Miller BL, Kosik KS. (2020) Alzheimer’s & Dementia  

COVID-19 in older people with cognitive impairment in Latin America.

Ibanez A, Santamaria-Garcia H, Barragan AG, Kornhuber A, Ton AMM, Slachevsky A, Teixeira AL, Meza BMM, Serrano CM, Cano C, Gonzalez CA, Butler C, Duran-Aniotz C, Acosta D, Matallana DL, Acosta-Alvear D, Trépel D, Resende EDPF, De Felice FG, Navarrete G, Tarnanas I, Meier IB, Smid J, Bustin J, Fajersztajn L, Takada LT, Duque L, Bicalho MAC, Behrens MI, Pintado-Caipa M, Wilson MZ, Puebla MDLC, Custodio N, Santibanez R, Serafim RB, Tavares RM, Escudero SDP, Rodriguez TL, Dawson W, Miller B, Kosik KS. (2020) Lancet Neurology

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System.

De Felice FG, Tovar-Moll F, Moll J, Munoz DP & Ferreira ST. (2020)Trends in Neuroscience 

The effect of lumbar puncture on the neurodegeneration biomarker neurofilament light in macaque monkeys.

Boehnke SE, Robertson EL, Armitage-Brown B, Wither RG, Lyra E Silva NM, Winterborn A, Levy R, Cook DJ, De Felice FG, Munoz DP (2020)  Alzheimer's & Dementia (Amst)  

Protective actions of exercise-related FNDC5/Irisin in memory and Alzheimer’s disease.

 De Freitas, GB; Lourenço, MV; De Felice, FG. (2020) Journal of Neurochemistry

Insulin and leptin as potential cognitive enhancers in metabolic disorders and Alzheimer's disease.

Mejido DCP, Andrade J, Vieira, MNN, Ferreira ST, De Felice FG. (2020) Neuropharmacology 

Cerebrospinal fluid irisin correlates with amyloid-b, BDNF and cognition in Alzheimer’s disease.

Lourenco MV, Ribeiro FC, Sudo FK, Drummond C, Assunção N, Vanderborght B, Tovar-Moll F, Mattos P, De Felice FG*, Ferreira ST* (2020) Alzheimer's & Dementia (Amst.) 

Behavioral abnormalities in knockout and humanized tau mice.

Gonçalves RA, Wijesekara N, Fraser PE, De Felice FG. (2020) Frontiers in Endocrinology

Palmitate is increased in the cerebrospinal fluid of humans with obesity and induces memory impairment in mice via pro-inflammatory TNF-α.

Melo HM, Seixas da Silva GS, Costa B,, Clarke JR, Figueiredo CP, Klein WL, Checler F, Velloso LA, Balthazar M, Cintra D, Ferreira ST, De Felice FG. (2020) Cell Reports 

Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice.

Figueiredo CP, Souza INO, Frost PS, França JV, Nascimento-Viana J, Neris RLS, Freitas L, Pinheiro DJLL, Neves G, Chimelli L, De Felice FG, Assunção-Miranda I, Clarke JR, Da Poian AT, Ferreira ST. (2019) Nature Communications. 

Association between diabetes and mood disorders and the potential use of anti-hyperglycemic agents as antidepressants. 

Grigolon RB, Brietzke E, Mansur RB, Idzikowski MA, Gerchman F, De Felice FG & McIntyre RS. (2019) Progress in Neuro-Psychopharmacology and Biological Psychiatry

Extracellular vesicles derived from human Wharton’s Jelly mesenchymal stem cells protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers.

Bodart-Santos V, Carvalho LRP, de Godoy MA, Batista AF, Saraiva, LM, Lima LG, De Felice FG, Galina A, Mendez-Otero R, Ferreira ST. (2019)  Stem Cell Research & Therapy

Potentials and Pitfalls of Cross-Translational Models of Cognitive Impairment. 

Al Dahhan NZ, De Felice FG, Munoz DP. (2019) Frontiers in Behavioral Neuroscience

Insulin resistance as a shared pathogenic mechanism between Depression and Type 2 diabetes., Research Topic “Brain-Metabolic Crossroads in Severe Mental Disorders”. 

Lyra e Silva N, Lam M, Soares CN, Munoz DP, Milev R, De Felice FG. (2019) Frontiers in Psychiatry 

Understanding the link between insulin resistance and Alzheimer's disease: Insights from animal models.

Lyra E Silva NM, Gonçalves RA, Boehnke SE, Forny-Germano L, Munoz DP, De Felice FG. (2019) Experimental Neurology

The Role of Leptin and Adiponectin in Obesity-Associated Cognitive Decline and Alzheimer’s disease.

Forny-Germano L, De Felice FG, Vieira MNN. (2019) Frontiers in Neuroscience

The link between Tau and insulin signalling: Implications for Alzheimer’s disease and other tauopathies.

Goncalves RA, Wijesekara N, Fraser PE, De Felice FG. (2019)  Frontiers in Cellular Neuroscience 

Neonatal infection leads to increased susceptibility to Aβ oligomer-induced brain inflammation, synapse loss and cognitive impairment in mice.

Frost P, Venancio A, Telles R, Matias I, Barros-Aragão F., Lyra e Silva N., Kincheski G., De Felice FG, Gomes FA, Ferreira ST, Figueiredo C, Clarke J. (2019) Cell Death & Disease 

Long-term consequences of the absence of leptin signaling in early life.

Ramos-Lobo AM, Teixeira PDS, Furigo IC, Melo HM, Lyra e Silva NM, Vianna CR, Elmquist JK, De Felice FG and Donato Jr J. (2019) eLife 

Exercise-linked FNDC5/irisin rescues synapse and memory defects in Alzheimer’s models.

Lourenco MV, Frozza RL, de Freitas GB, Zhang H, Kincheski GC, Clarke JR, Ribeiro FC, Beckman D, Staniszevski A, Berman HL, Guerra LA, Forny-Germano L, Meier S, Abisambra JF, Wilcock DM, Prado VF, Prado MAM, de Souza JM, Alves-Leon SV, Tovar-Moll F, Mattos P, Arancio O, Ferreira ST, De Felice FG. (2019) Nature Medicine

The link between Tau and insulin signalling: Implications for Alzheimer’s disease and other tauopathies. 

Goncalves RA, Wijesekara N, Fraser PE, De Felice FG. (2019) Frontiers in Cellular Neuroscience

The Role of Leptin and Adiponectin in Obesity-Associated Cognitive Decline and Alzheimer’s disease. 

Forny-Germano L, De Felice FG, Vieira MNN. (2018). Frontiers in Neuroscience

Neuroprotective Actions of Glucagon-Like Peptide-1 (GLP-1) Analogues in Alzheimer’s and Parkinson’s Diseases. 

Batista AF, Bodart-Santos V, De Felice* FG, Ferreira ST*. (2018) CNS Drugs 

Insulin resistance in Alzheimer’s Disease.

Ferreira LSS, Fernandes CS, Vieira MN, De Felice FG. (2018) Frontiers in Neuroscience

Acute and chronic neurological consequences of early-life Zika virus infection in mice.

Nem de Oliveira Souza I, Frost PS, França JV, Nascimento-Viana JB, Neris RLS, Freitas L, Pinheiro DJLL, Nogueira CO, Neves G, Chimelli L, De Felice FG, Cavalheiro ÉA, Ferreira ST, Assunção-Miranda I, Figueiredo CP, Da Poian AT, Clarke JR. (2018). Science Translational Medicine  

Expression of dopamine signaling genes is decreased in the brains of individuals with mental illnesses is moderated by body mass index and mediated by insulin signaling genes.

Mansur RB, Fries GR, SubramaniapillaiM, Frangou S, De Felice FG, Rasgon N, McEwen, Brietzke E, McIntyre RS. (2018) Journal of Psychiatric Research 

Free-floating adult human brain-derived slice cultures as a model to study the neuronal impact of Alzheimer's disease-associated Aβ oligomers.

Mendes ND, Fernandes A, Almeida GM, Santos LE, Selles MC, Lyra-Silva N, Louzada PR, De Felice FG, Alvez-Leon S, Marcondes J, Assirati Jr. JA; Matias CM, Klein WL, Garcia-Cairasco N, Ferreira ST, Neder L, Sebollela A. (2018) Journal of Neuroscience Methods

Metabolic syndrome and cognitive decline in the elderly: A Systematic Review.

Assuncao N, Suko FK, Drummond C, De Felice FG, Mattos P (2018) PLoS One 

Brain STAT5 signaling modulates learning and memory formation.

Furigo I., Melo HM, Lyra e Silva N, Ramos-Lobo A, Teixeira P, Buonfiglio D, Lima E, Higuti E, Peroni C, Bartolini P, Soares C, List E, Kopchick J, Metzger M, De Felice FG, Donato Jr. JD. (2018) Brain Structure and Function

Metabolic Dysfunction in Alzheimer’s Disease: From Basic Neurobiology to Clinical Approaches.

Clarke JR Frozza R, Ribeiro FC, De Felice FG, Lourenco MV. (2018) Journal of Alzheimer's Disease

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer’s disease.

Batista AF, Forny-Germano L, Clarke JR, Lyra e Silva NM, Brito-Moreira J, Boehnke SE, Winterborn A, Coe BC, Lablans A, Fontes J, Marques S, Gralle M, Holscher C, Klein WL, Houzel J-C, Ferreira ST, Munoz DP, De Felice FG (2018) Journal of Pathology

Challenges for Alzheimer's disease therapy: insights from novel mechanisms beyond memory defects. 

Frozza R, Lourenco MV, De Felice FG. (2018) Special issue on “The Alzheimer's Disease Challenge”. Frontiers in Neuroscience

Mesenchymal stem cells protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers.

de Godoy MA, Saraiva LM, de Carvalho LRP, Vasconcelos-dos-Santos A, Beiral HJV, de Paula Silva LR, Leal RB, Monteiro VHS, Braga CV, de Araujo e Silva CA, Sinis LC, Lima APCA, da Cunha e Silva NL, Galina-Filho A, Vieyra A, De Felice FG, Mendez-Otero R, Ferreira ST (2018)  Journal of Biological Chemistry

Tau ablation leads to pancreatic beta cell dysfunction and glucose intolerance.

Wijesekara N, Gonçalves R, Ahrens R., De Felice FG, Fraser P. (2018) FASEB J. 

Impaired Peripheral Glucose Homeostasis and Alzheimer's Disease.

Wijesekara N, Gonçalves R, De Felice FG, Fraser P. (2018) Neuropharmacology

Connecting Alzheimer's disease to Diabetes: underlying mechanisms and potential treatments. 

Vieira MN, Lima-Filho RAS, De Felice FG. (2018) Special issue on “Metabolic impairment as risk factors for neurodegenerative disorders.” Neuropharmacology

Insulin receptor activation stimulates the endocytic processing of surface-bound Aβ oligomers leading to their extracellular release.

Pitt J, Wilcox KC, Tortelli V, Oliveira MS, Dobbins C, Yu X-W, Diniz LP, Nandamuri S, FCA Gomes, De Felice FG, Ferreira ST, Klein WL (2017)  Molecular Biology of the Cell

Brain infusion of α-synuclein oligomers induces motor and non-motor Parkinson's disease-like symptoms in mice.

Fortuna JT, Gralle MD, Beckman D, Neves FS, Diniz LP, Barros-Aragão F, Santos LE, Gonçalves RA, Romao L, Zamberlan DC, Soares FA, Braga C, Foguel D, Gomes FA, De Felice FG, Ferreira ST, Clarke J, Figueiredo CP (2017)  Behavioural Brain Research

Astrocyte Transforming Growth Factor Beta 1 Protects Synapses against Aβ Oligomers in Alzheimer's Disease Model.

Diniz LP, Tortelli V, Matias I, Morgado J, Bérgamo AP, Melo HM, Seixas da Silva GS, Alves-Leon SV, JM de Souza, Ferreira ST, De Felice FG, Gomes FCA (2017)  Journal of Neuroscience 

Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice. 

Kincheski G, Valentim IS, Clarke JR, Ferreira DC, Castelo-Branco MTL, Ramos-Lobo AM, Rumjanek VMBD, Donato Jr. J, De Felice FG, Ferreira ST (2017) Brain, Behavior, and Immunity

Amyloid-β oligomers Transiently Inhibit AMP-activated kinase and Cause Metabolic Defects in Hippocampal Neurons.

Seixas da Silva GS, Melo HM, Lourenço MV, Lyra e Silva NM, Carvalho MB, Alves-Leon S, de Souza JM, Klein WL, da-Silva WS, Ferreira ST, De Felice FG (2017)  Journal of Biological Chemistry

Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice.

Brito-Moreira J, Lourenco MV, Oliveira MM, Fontes J, Ribeiro FC, Ledo JH, Diniz LP, Magdesian MH, Melo HM, de Souza JM, Alves-Leon S, Gomes FCA, Clarke JR, Figueiredo CP, De Felice FG, Ferreira ST (2017)  Journal of  Biological Chemistry 

Brain-Defective Insulin Signaling Is Associated to Late Cognitive Impairment in Post-Septic Mice. 

Neves FS, Marques PT, Barros-Aragão F, Nunes JB, Venancio AM, Cozachenco D, Frozza RL, Passos GF, Costa R, de Oliveira J, Engel DF, De Bem AF, Benjamim CF, De Felice FG, Ferreira ST, Clarke JR, Figueiredo CP. (2017) Molecular Neurobiology

Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer’s Therapy?

Vieira MN, Lyra e Silva NM, Ferreira ST, De Felice FG (2017) Frontiers in Aging Neuroscience 

Getting a "GRiP" on Hypothalamic Endoplasmic Reticulum Stress to Combat Obesity. 

De Felice FG, Ferreira ST. (2017) Diabetes. 

Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid-β Oligomers in Mice.

Ledo JH, Azevedo EP, Beckman D, Ribeiro FC, Santos LE, Razolli DS, Kincheski GC, Melo HM, Bellio M, Teixeira AL, Velloso LA, Foguel D, De Felice FG, Ferreira ST. (2016)  Journal of Neuroscience 

Opportunities and challenges in developing relevant animal models for Alzheimer's disease. 

De Felice FG & Munoz D.P. (2016) Ageing Research Reviews 

A key role of insulin receptors in memory.

De Felice FG & Benedict C. (2015) Diabetes 

Neuronal stress signaling and eIF2a phosphorylation as molecular links between Alzheimer's disease and diabetes.

Lourenço MV, Ferreira ST, De Felice FG. (2015) Progress in Neurobiology

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease.

Ferreira ST, Lourenco MV, Oliveira MM, De Felice FG (2015) Frontiers in Cellular Neuroscience

Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer's disease.

De Felice FG, Lourenco MV (2015) Frontiers in Aging Neuroscience

Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation. 

Clarke JR, Lyra e Silva NM, Bomfim TR, Frozza RL, Katashima CK, Razolli D, Carvalho BM, Ribeiro FC, Costa CV, Ledo JH, Beckman D, Klein WL, Munoz DP, Saad MJ, Carvalheira JB, Velloso LA, Figueiredo CP, Ferreira ST, De Felice FG (2015) EMBO Molecular Medicine  

Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.

Forny-Germano L, Lyra e Silva NN, Batista AF, Brito-Moreira J, Gralle M, Boehnke S., Coe B, Lablans A, Marques SA, Martinez AMB, Klein WL, Houzel J-C, Ferreira ST, Munoz DP & De Felice FG. (2014)  Journal of Neuroscience 

Inflammation and defective insulin signaling as common molecular denominators connecting Type 2 diabetes and Alzheimers disease.

De Felice, FG & Ferreira ST. (2014) Diabetes 

Astrocyte transforming growth factor beta 1 promotes inhibitory synapse formation via cam kinase II signaling.

Diniz LP, Tortelli V, Garcia MN, Bérgamo AP, Melo HM, Seixas da Silva GS, De Felice FG, Alves- Leon SV, de Souza JM, Romão LF, Gomes FCA. (2014) Glia 

Inflammation, defective insulin signaling and neuronal dysfunction in Alzheimer’s disease. 

Ferreira ST; Clarke, JR; Bomfim, TR; De Felice, FG. (2014) Alzheimer’s & Dementia 

How does brain insulin resistance develop in Alzheimer’s disease? 

De Felice, FG; Lourenco MV; Ferreira ST. (2014) Alzheimer’s & Dementia 

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer's β-Amyloid Oligomers in Mice and Monkeys.

Lourenço MV, Clarke JR, Frozza RL, Bomfim TR, Forny-Germano L, Batista AF, Sathler LB, Brito- Moreira J, Amaral OB, Silva CA, Freitas-Correa L, Espírito-Santo S, Campello-Costa P, Houzel J-C, Klein WL, Holscher C, Carvalheira JB, Silva AM, Velloso LA, Munoz DP, Ferreira ST, De Felice FG (2013) Cell Metabolism

Connecting type 2 diabetes to Alzheimer's disease.

De Felice FG. (2013)  Expert Review of Neurotherapeutics

Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence. 

Freiherr J; Hallschimid M.; Frey II, WH; Craft S; De Felice, FG; Benedict C. (2013) CNS Drugs 

Memantine prevents transient cognitive impairment caused by high molecular weight Aβ oligomers but not the persistent impairment induced by low molecular weight oligomers.

Figueiredo CP, Clarke JR, Mota-Sales AP, Ribeiro FC, Ledo JH, Valente C, Melo HM, Sebollela A, Klein WL, De Felice, FG, Ferreira ST. (2013)  Journal of Neuroscience

Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice.

Ledo JH, Azevedo EP, Clarke JR, Ribeiro FC, Figueiredo CP, Foguel D, De Felice, FG, Ferreira ST (2013) Molecular Psychiatry 

Alzheimer's disease and insulin resistance: translating basic science into clinical applications. 

De Felice, FG (2013) Journal of Clinical Investigation

An anti-diabetic agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s toxic Aβ oligomers.

Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel J-C, Decker H, Silverman MA, Kazi H, Melo HM, McClean PL, Holscher C, Arnold SE, Talbot K, Klein WL, Munoz DP, Ferreira ST, De Felice, FG (2012)  Journal of Clinical Investigation

Amyloid-β oligomers induce differential gene expression in adult human brain slices.

Sebollela A, Freitas-Correa L, Oliveira FF, Paula-Lima AC, Saraiva LM, Martins SM, Carvalho Mota LD Torres C, Alves-Leon S, de Souza JM, Carraro DM, Brentani H, De De Felice, FG, Ferreira ST. (2012)  Journal of Biological Chemistry

Amyloid-beta oligomers increase the localization of prion protein at the cell surface.

Caetano FA, Beraldo FH, Hajj GN, Guimaraes AL, Jürgensen S, Wasilewska-Sampaio AP, Hirata PH, Souza I, Machado CF, Wong DY, De Felice, FG, Ferreira ST, Prado VF, Rylett RJ, Martins VR, Prado MA. (2011) Journal of Neurochemistry

Activation of D1/D5 dopamine receptors protects neurons from synapse dysfunction induced by amyloid-beta oligomers. 

Jürgensen, S, Antonio LL, Mussi, GE, Brito-Moreira, J, Bomfim, TR, De Felice, FG, Garrido-Sanabria ER, Cavalheiro EA and Ferreira, ST (2011) Journal of Biological Chemistry 

Amyloid-beta Triggers the Release of Neuronal Hexokinase 1 from Mitochondria.

Saraiva, LM, Seixas da Silva, GS, Galina, A, Da Silva, WS, Klein, WL, Ferreira, ST and De Felice, FG (2010)  PloS ONE  

Expression profile of rat hippocampal neurons treated with the neuroprotective compound 2,4-dinitrophenol: Up-regulation of cAMP signaling genes.

Sebollela, A, Corrêa, LF, Oliveira, FF, Pereira, JC, Galina, A, Wasilewska-Sampaio, AP, Brentani, HP, Passetti, F, De Felice, FG, Dias-Neto, E. and Ferreira, S.T. (2010)  Neurotox. Res. 18: 112-123. 

N-methyl-D-aspartate receptors are required for synaptic targeting of beta oligomers.

Decker, H, Jürgensen, S, Bomfim, TR, Brito-Moreira, J, Klein, WL, De Felice, FG and Ferreira, ST (2010) Journal of Neurochemistry

Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal.

Pitts, J, Roth W, Lacor, P, Smith AB, Blankenship, M, Velasco, PT, De Felice, FG, Breslin, P and Klein, WL (2009)  Toxicology and Applied Pharmacology

Protection of synapses against Alzheimer’s-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

De Felice, FG, Vieira, MNN, Decker, H, Bomfim, TR, Velasco PT, Lambert, MP, Viola, KL, Zhao WQ, Ferreira, ST and Klein, WL (2009). Proceedings of the National Academy of Sciences of the United States of America